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Article

A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Dec 2015

Mihaila Romeo Gabriel

Abstract excerpt

BACKGROUND: Na(+)/H(+) exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in...

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Identifiers

PMID: 26725705
DOI: 10.5507/bp.2015.060

Genes

FLT3

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