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Article

Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced proinflammatory potential are enriched in the adult human liver.

European journal of immunology - 1 Sept 2016

Harmon Cathal, Robinson Mark W, Fahey Ronan, Whelan Sarah, Houlihan Diarmaid D, Geoghegan Justin, O'Farrelly Cliona

Abstract excerpt

The adult human liver is enriched with natural killer (NK) cells, accounting for 30-50% of hepatic lymphocytes, which include tissue-resident hepatic NK-cell subpopulations, distinct from peripheral blood NK cells. In murine liver, a subset of liver-resident hepatic NK cells have altered expression of the two highly related T-box transcription factors, T-bet and eomesodermin (Eomes). Here, we investigate the...

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CD56 Antigen
Cell Degranulation
Cytotoxicity, Immunologic
Immune Tolerance
Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NK Cell Lectin-Like Receptor Subfamily K

T-bet Transcription Factor

T-Box Domain Proteins

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Identifiers

PMID: 27485474
DOI: 10.1002/eji.201646559

Genes

CXCR6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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