Article

Myeloid Suclg2 deficiency attenuates aortic dissection by reshaping succinate-associated macrophage remodelling

2026-06-25

Abstract excerpt

<h4>Background</h4> Succinate has emerged as an immunometabolic mediator of cardiovascular diseases. However, the enzymatic mechanisms linking macrophage succinate metabolism to aortic dissection remain incompletely understood. This study investigated whether Suclg2, which encodes the GDP-forming β-subunit of succinyl-CoA ligase, regulates succinate-associated macrophage remodelling and aortic dissection progress...

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Literature Corpus work: 90d35d4d-a7f5-5da9-9538-e991752d1d19
DOI: 10.64898/2026.06.24.734396

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