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Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activity

2023-06-04

Abstract excerpt

<h4>Introduction</h4> Lysine succinylation is a post-translational modification associated with the control of several diseases, including acute kidney injury (AKI). It is suggested that hypersuccinylation favors peroxisomal fatty acid oxidation (FAO) instead of mitochondrial. In addition, the medium-chain fatty acids (MCFAs) dodecanedioic acid (DC 12 ) and octanedioic acid (DC 8 ), upon FAO, generate succinyl-...

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Literature Corpus work
99ccb6af-5e61-5ba8-94c6-85fba18f1a7b
DOI
10.1101/2023.05.31.543068
Open publication

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Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activityDOI 10.1101/2023.05.31.543068
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