Gut microbial-derived short chain fatty acids enhance kidney proximal tubule cell secretory function

Abstract excerpt

The organic anion transporter-1 (OAT1), located at the basal side of kidney proximal tubule cells, is actively involved in metabolic waste excretion. During chronic kidney disease (CKD), the progressive decline in renal function, results in the accumulation of endogenous metabolites in the bloodstream, exacerbating comorbidities. CKD also leads to gut dysbiosis, resulting in an increased production of uremic metab...

Topics

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• Adolescent and Pediatric Healthcare
• Clostridium difficile and Clostridium perfringens research
• Dialysis and Renal Disease Management
• Diet and metabolism studies
• Digestive system and related health
• Gut microbiota and health
• Kidney Stones and Urolithiasis Treatments
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

76929bc5-d4f7-541e-b247-c0b06bb45d92

DOI

10.1101/2025.02.20.639317