Article
Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration.
Cell death and differentiation - 1 Apr 2013
Behan A T, Breen B, Hogg M, Woods I, Coughlan K, Mitchem M, Prehn J H M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition with no cure. Mitochondrial dysfunction, Ca(2+) overloading and local hypoxic/ischemic environments have been implicated in the pathophysiology of ALS and are conditions that may initiate metabolic acidosis in the affected tissue. We tested the hypothesis that acidotoxicity and acid-sensing ion channels (ASICs) are involved in the...
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