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Article

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.

Human molecular genetics - 15 Oct 2008

Wong Hon Kit, Bauer Peter O, Kurosawa Masaru, Goswami Anand, Washizu Chika, Machida Yoko, Tosaki Asako, Yamada Mizuki, Knöpfel Thomas, Nakamura Takemichi, Nukina Nobuyuki

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disorder. Despite a tremendous effort to develop therapeutic tools in several HD models, there is no effective cure at present. Acidosis has been observed previously in cellular and in in vivo models as well as in the brains of HD patients. H...

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PMID: 18658163
DOI: 10.1093/hmg/ddn218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18658163-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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