Article

Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer’s disease mouse model via enhancing neurotrophic and synaptic signaling

2024-06-16

Abstract excerpt

<h4>INTRODUCTION</h4> Skeletal muscle regulates central nervous system (CNS) function and health, activating the muscle-to-brain axis through the secretion of skeletal muscle originating factors (‘myokines’) with neuroprotective properties. However, the precise mechanisms underlying these benefits in the context of Alzheimer’s disease (AD) remain poorly understood. <h4>METHODS</h4> To investigate muscle-to-brain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1efeba38-ddf8-51da-82bb-bb93df666ec7
DOI: 10.1101/2024.06.14.599115

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer’s disease mouse model via enhancing neurotrophic and synaptic signalingDOI 10.1101/2024.06.14.599115Read

Skeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative DiseaseSemantic proximity Read

Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative diseaseSemantic proximity Read

Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s diseaseSemantic proximity Read

Skeletal Muscle Proteostasis Promotes Central Nervous System Rejuvenation and Reduces Neuroinflammation during Aging and Neurodegenerative DiseaseSemantic proximity Read

Sarcopenia as a Risk Factor for Alzheimer’s Disease: Genetic and Epigenetic PerspectivesSemantic proximity Read

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and functionSemantic proximity Read

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse modelSemantic proximity Read

Sexual dimorphism in behavior, neuropathology, and biomarkers in a tau P301S mouse model of Alzheimer’s diseaseSemantic proximity Read

Muscle spatial lipidomics identifies early ALS-associated lipid remodeling in presymptomatic SOD1G93A miceSemantic proximity Read

Retrospective Study of the Physiological and Molecular Features of the S-FUS (1-359) Mouse Transgenic Model with an ALS-like Phenotype: Lifespan, Body Weight Dynamics, Movement Disorders, and Dysregulation of the Dopaminergic System.Semantic proximity Read

Role of the Insulin-like Growth Factor System in Neurodegenerative DiseaseSemantic proximity Read

Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathwaysSemantic proximity Read