Article
Retrospective Study of the Physiological and Molecular Features of the S-FUS (1-359) Mouse Transgenic Model with an ALS-like Phenotype: Lifespan, Body Weight Dynamics, Movement Disorders, and Dysregulation of the Dopaminergic System.
Journal of molecular neuroscience : MN - 8 Jan 2026
Bronovitsky Evgeny, Chaprov Kirill, Khizeva Anastasia, Ivanova Tamara, Pravdivceva Ekaterina, Bobkov Timofey, Morozova Olga, Krayushkina Anastasia, Nebogatikov Vladimir, Ninkina Natalia, Ustyugov Aleksey
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease leading to disability and death. Genetic animal models, like transgenic mice, are critical for studying disease mechanisms and developing therapies. Model validity, experimental standardization, and predictability are key to successful research. This retrospective study analyzed physiological parameters of the S-FUS (1-359) transgenic mouse...
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