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Article

Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s disease

10 Nov 2022

Abstract excerpt

Abstract Alzheimer’s disease (AD) is the most common form of dementia. Notably, patients with AD often suffer from severe sarcopenia. However, their direct link and relationship remain poorly understood. Here, we generated a mouse line, TgAPPsweHSA, by crossing LSL (LoxP-STOP-LoxP)-APPswe with HSA-Cre mice, which express APPswe (Swedish mutant APP) selectively in skeletal muscles. Examining phenotypes in...

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PMID: 36357367
DOI: 10.1038/s41419-022-05378-4

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