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Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

3 May 2016

Abstract excerpt

The evidence for a protective role of physical activity on the risk and progression of Alzheimer's disease (AD) has been growing in the last years. Here we studied the influence of a prolonged physical and cognitive stimulation on neurodegeneration, with special emphasis on hippocampal neuron loss and associated behavioral impairment in the Tg4-42 mouse model of AD. Tg4-42 mice overexpress Aβ4-42 without any...

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PMID: 27138799
DOI: 10.1038/tp.2016.65

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