Article

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function

2023-11-17

Abstract excerpt

<h4>Summary</h4> Tauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy. However, whether neuronal pathological tau species confer muscle weakness, and whether skeletal muscle maintains contractile capacity in primary tauopathy remains unknown....

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Literature Corpus work: 69fe16cb-0ef6-5d50-92b3-697a94110fa2
DOI: 10.1101/2023.11.17.567586

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