Article

Significant value of p53 accumulated in Invasive Ductal Breast Carcinoma

2024-03-06

Abstract excerpt

<h4>Background: </h4> The presence of a functional p53 protein is a key factor for the appropriate suppression of cancer development. The tumor suppressor p53 accumulates under stressful conditions, such as DNA damage, heat shock, hypoxia, and/or proto-oncogene activation, although conflicting reports exist on its transcriptional activity. A loss of p53 activity, by mutations or inhibition, is often associated wit...

Topics

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Antineoplastic Agents, Hormonal
Breast Neoplasms
Cancer-related Molecular Pathways
Heat shock proteins research
Mutation
Receptors, Estrogen
Receptors, Progesterone
Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work: 1efa51ca-d5fa-537a-9a29-8415df3414bc
DOI: 10.21203/rs.3.rs-4010877/v1

Open publication