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The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers

17 Nov 2009

Abstract excerpt

We hypothesized that the functional status of p53 transcriptional pathways, rather than p53 protein expression alone, could accurately discriminate between low- and high-risk breast carcinoma (BC) and inform about individuals' tumour biological behaviour. To test this, we studied a well-characterized series of 990 BCs with long-term follow-up, immunohistochemically profiled for p53, its main regulators and...

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PMID: 20044801
DOI: 10.1002/path.2663

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