Article
TP53 status and response to chemotherapy in breast cancer.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2008
Bertheau Philippe, Espié Marc, Turpin Elisabeth, Lehmann Jacqueline, Plassa Louis-François, Varna Mariana, Janin Anne, de Thé Hugues
Abstract excerpt
Despite its central role in the control of apoptosis, senescence and cell cycle arrest, the tumor suppressor protein p53 remains an enigma for its possible role in predicting response to chemotherapy in cancer patients. Many studies remained inconclusive, others showed a better response for tumors with normal p53, and some recent studies showed adverse effects of normal p53 for response to treatment. p53 is not...
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