Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

High p53 Protein Level Is a Negative Prognostic Marker for Pancreatic Adenocarcinoma.

International journal of molecular sciences - 16 Nov 2024

Klein Sebastian M, Bozko Maria, Toennießen Astrid, Rangno Dennis, Bozko Przemyslaw

Abstract excerpt

Pancreatic adenocarcinoma is one of the most aggressive types of cancer. Among different mechanisms generally believed to be important for the development of cancer, aberrant regulation of the p53 protein is a well-known and common feature for many cancer entities. Our work aims to analyze the impact of p53 deregulation and proteins encoded by p53 target genes on the survival of patients suffering from pancreatic...

Topics

Humans
Pancreatic Neoplasms
Tumor Suppressor Protein p53
Prognosis
Adenocarcinoma
Biomarkers, Tumor
Mutation
Female
Male
Middle Aged
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 39596373
DOI: 10.3390/ijms252212307
PMCID: PMC11594790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High p53 Protein Level Is a Negative Prognostic Marker for Pancreatic Adenocarcinoma.PMID 39596373Read ↗

p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer.Semantic proximity Read ↗

A novel tp53-associated nomogram to predict the overall survival in patients with pancreatic cancer.Semantic proximity Read ↗

Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.Semantic proximity Read ↗

[Molecular mechanism in pathogenesis of pancreatic cancers: P53 oncosuppressive gene].Semantic proximity Read ↗

[Molecular factors of pancreatic cancer pathogenesis and prognosis].Semantic proximity Read ↗

Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished AffairSemantic proximity Read ↗

[Prognostic value of important driver gene mutations in patients with radical resection of pancreatic cancer].Semantic proximity Read ↗

Apoptosis: targets in pancreatic cancer.Semantic proximity Read ↗

Role of p53 mutations on survival after pancreatoduodenectomy for ductal adenocarcinoma of the pancreatic head.Semantic proximity Read ↗

[Molecular predictors for the course of disease and individualized therapy in pancreatic cancer].Semantic proximity Read ↗

Advances in understanding the roles of TP53 mutations in pancreatic and hepatobiliary cancers.Semantic proximity Read ↗

Alterations of the TP53 gene in gastric and esophageal carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.