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Article

Assessment of changes in the BRCA2 and P53 genes in breast invasive ductal carcinoma in northeast Brazil.

Biological research - 26 Mar 2014

Ramalho Eduardo Avf, Silva-Filho João Lq, Cartaxo Marina Fs, Cavalcanti Carmelita Bl, Rêgo Moacyr Jbm, Oliveira Maria Bm, Beltrão Eduardo Ic

Abstract excerpt

BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for...

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Source

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Identifiers

PMID: 25027116
DOI: 10.1186/0717-6287-47-3
PMCID: PMC4060371

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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