Article

Joint analysis of matched tumor samples with varying tumor contents improves somatic variant calling in the absence of a germline sample

2018-07-09

Abstract excerpt

Archival tumor samples represent a potential rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the retrospective setting, making it difficult to distinguish between true somatic variants and germline variants that are private to the individual. Archival sect...

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Literature Corpus work: 1ef810ad-f466-542d-87a7-88bbfa652080
DOI: 10.1101/364943

Open publication

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