Evaluating somatic tumor mutation detection without matched normal samples.

Abstract excerpt

BACKGROUND: Observations of recurrent somatic mutations in tumors have led to identification and definition of signaling and other pathways that are important for cancer progression and therapeutic targeting. As tumor cells contain both an individual's inherited genetic variants and somatic mutations, challenges arise in distinguishing these events in massively parallel sequencing datasets. Typically, both a...

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• Databases, Factual
• DNA Mutational Analysis
• Genotype
• High-Throughput Nucleotide Sequencing
• Mutation