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Article

Discriminating somatic and germline mutations in tumor DNA samples without matching normals.

Genome research - 1 Sept 2015

Hiltemann Saskia, Jenster Guido, Trapman Jan, van der Spek Peter, Stubbs Andrew

Abstract excerpt

Tumor analyses commonly employ a correction with a matched normal (MN), a sample from healthy tissue of the same individual, in order to distinguish germline mutations from somatic mutations. Since the majority of variants found in an individual are thought to be common within the population, we constructed a set of 931 samples from healthy, unrelated individuals, originating from two different sequencing...

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Identifiers

PMID: 26209359
DOI: 10.1101/gr.183053.114
PMCID: PMC4561496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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