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Conpair: concordance and contamination estimator for matched tumor–normal pairs

26 Jun 2016

Abstract excerpt

MOTIVATION: Sequencing of matched tumor and normal samples is the standard study design for reliable detection of somatic alterations. However, even very low levels of cross-sample contamination significantly impact calling of somatic mutations, because contaminant germline variants can be incorrectly interpreted as somatic. There are currently no sequence-only based methods that reliably estimate contamination...

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PMID: 27354699
DOI: 10.1093/bioinformatics/btw389

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