Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors

Abstract excerpt

CD28 ligation provides critical signals that modulate activated T cell fate. In a human to mouse reverse-engineering approach, a single amino acid substitution adjacent to the C-terminal proline-rich domain created CD28 A210P mice with enhanced signaling. CD28 A210P mice experienced pro-inflammatory responses to CD28 superagonist antibody, analogous to severe cytokine storm induced in a human clinical trial, wit...

Topics

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• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• CD28 Antigens
• Immune Cell Function and Interaction
• Immunotherapy, Adoptive
• NFATC Transcription Factors
• NIH 3T3 Cells
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

10799abb-ad96-5705-8e76-e7fdf90e0204

DOI

10.1101/2025.03.10.642460