Article

Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

2024-06-13

Abstract excerpt

Mutations of the glucocerebrosidase-encoding gene, GBA1 , are common risk factors for Parkinson’s disease. Although only a minority of mutation-carrying individuals develops the disease, the mechanisms of neuronal vulnerability predisposing to pathology conversion remain largely unclear. In this study, heterozygous expression of a common glucocerebrosidase variant, namely the L444P mutation, was found to exacerba...

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Literature Corpus work: 1ef18060-39ea-5630-b94f-e03931d7266c
DOI: 10.1101/2024.06.13.598820

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