Article

A human <i>GBA-L444P</i> transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson’s disease

2026-05-27

Abstract excerpt

<h4>Background</h4> Heterozygous mutations in the GBA1 gene encoding the enzyme glucocerebrosidase (GCase) represent the most common genetic risk factor for developing Parkinson’s disease (PD). The underlying mechanisms by which GBA1 mutations lead to PD through both loss- and gain-of-function effects remain unclear. There is a strong rationale for the generation and characterisation of a humanised GBA1 mouse...

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Literature Corpus work: ea98ff14-3fa0-5c2a-b52f-9b70ef3e599b
DOI: 10.64898/2026.05.25.727583

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