Article

Antibody treatment targeting nitrated alpha-synuclein counteracts protein spreading pathology

2026-05-26

Abstract excerpt

α-Synuclein nitration is a prominent post-translational modification in Parkinson’s disease, but whether nitrated α-synuclein merely reflects oxidative stress or actively contributes to pathology remains unclear. Here, we generated and characterized 6G6, an antibody selective for Tyr39-nitrated α-synuclein, and tested whether targeting this modified α-synuclein species affected pathology in different mouse models...

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Literature Corpus work: cd45d9c9-274b-5ebc-a414-7506182ca8ba
DOI: 10.64898/2026.05.21.726933

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