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Article

Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.

Human molecular genetics - 1 Jul 2016

Rockenstein Edward, Clarke Jennifer, Viel Catherine, Panarello Nicholas, Treleaven Christopher M, Kim Changyoun, Spencer Brian, Adame Anthony, Park Hyejung, Dodge James C, Cheng Seng H, Shihabuddin Lamya S, Masliah E, Sardi S Pablo

Abstract excerpt

Mutations in GBA1, the gene encoding glucocerebrosidase, are associated with an enhanced risk of developing synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies. A higher prevalence and increased severity of motor and non-motor symptoms is observed in PD patients harboring mutant GBA1 alleles, suggesting a link between the gene or gene product and disease development. Interestingly, PD...

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Source

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Identifiers

PMID: 27126635
DOI: 10.1093/hmg/ddw124
PMCID: PMC5181635

Genes

GBA1
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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