Article

GBA1 mutations alter neuronal excitability and ultrastructure in Parkinson´s disease, regulating VGLUT2 and CRYAB in dopaminergic neurons

2024-12-16

Abstract excerpt

<title>Abstract</title> Mutations in the glucocerebrosidase 1 (<italic>GBA1</italic>) gene are major risk factors for Parkinson´s disease (PD), but their role in PD etiopathology is not fully understood. The impact of <italic>GBA1</italic> mutations on neuronal maturation, function and degeneration was investigated in dopaminergic (DA) neurons obtained from induced pluripotent stem cells (iPS cells/iPSCs) deri...

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Literature Corpus work: d5b9d7ef-9801-56ae-a4d8-4c576e6c1789
DOI: 10.21203/rs.3.rs-5434183/v1

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