Article
[Parkinson's disease associated with a mutation in the glucocerebrosidase gene].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2026
Sayfitdinkhazhaev Z F, Zhukova N G, Israilova G M, Zhukova I A, Masenko A Ya, Gaponova O V
Abstract excerpt
Parkinson's disease (PD) is one of the most socially significant neurodegenerative disorders due to its high prevalence and progressive nature. The key link in PD pathogenesis is the accumulation of the pathological alpha-synuclein. However, neuroinflammation, oxidative stress, mitochondrial dysfunction, and dysregulation of the brain-gut-microbiome axis also contribute significantly to the development of the...
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