Article

Inflammation induces pro-NETotic neutrophils via TNFR2 signaling

2021-06-22

Abstract excerpt

Cytokines released during chronic inflammatory diseases induce pro-inflammatory properties in polymorphonuclear neutrophils (PMN). Here we show that in vitro cytokine treatment leads to the development of a subgroup of human PMN expressing CCR5, termed CCR5 + cytokine-induced PMN (CCR5 + cPMN). Auto/paracrine TNF signaling increases intracellular neutrophil elastase (ELANE) abundance and induces NETosis in CCR5...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b03ad30-fea7-5b38-9f0d-f1b2c2546d8d
DOI: 10.1101/2021.06.21.448937

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inflammation induces pro-NETotic neutrophils via TNFR2 signalingDOI 10.1101/2021.06.21.448937Read

Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory PlasticitySemantic proximity Read

Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn’s disease through IFNα pathwaySemantic proximity Read

COVID-19 Hyperinflammation: What about Neutrophils?Semantic proximity Read

Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patientsSemantic proximity Read

Increased IL-8, Neutrophil Activation Phenotypes and NETosis in Critically Ill COVID-19 PatientsSemantic proximity Read

Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species and neutrophil extracellular trapsSemantic proximity Read

NETosis and the Immune System in COVID-19: Mechanisms and Potential TreatmentsSemantic proximity Read

Neutrophil-T cell crosstalk in inflammatory bowel disease.Semantic proximity Read

Molecular characterization of response to etrolizumab and anti-TNF reveals treatment resistance in ulcerative colitis is associated with an abundance of residual neutrophil subsets and inflammatory fibroblast populationsSemantic proximity Read

Neutrophil Extracellular Traps: Double-Edged Swords of Innate ImmunitySemantic proximity Read

Distinct Functional States of Neutrophils by Actin Disassembly and NF-kB/STAT3 SignalingSemantic proximity Read

The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory DiseasesSemantic proximity Read