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Article

Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.

PloS one - 1 Jan 2012

de Souza Camila Ferreira, Xander Patrícia, Monteiro Ana Carolina, Silva Amanda Gonçalves dos Santos, da Silva Débora Castanheira Pereira, Mai Sabine, Bernardo Viviane, Lopes José Daniel, Jasiulionis Miriam Galvonas

Abstract excerpt

BACKGROUND: Metastatic melanoma is a highly aggressive skin cancer and currently resistant to systemic therapy. Melanomas may involve genetic, epigenetic and metabolic abnormalities. Evidence is emerging that epigenetic changes might play a significant role in tumor cell plasticity and metastatic phenotype of melanoma cells. PRINCIPAL FINDINGS: In this study, we developed a systematic approach to identify genes...

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Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Metastasis

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Source

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Identifiers

PMID: 22984562
DOI: 10.1371/journal.pone.0044800
PMCID: PMC3439384

Genes

CTCF
HSPB1
NDRG2
NSD1
SERPINE1
SRC
VDR

Provenance

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