Article
The genome and epigenome of malignant melanoma.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Oct 2007
Dahl Christina, Guldberg Per
Abstract excerpt
Malignant melanoma originates in melanocytes, the pigment-producing cells of the skin and eye, and is one of the most deadly human cancers with no effective cure for metastatic disease. Like many other cancers, melanoma has both environmental and genetic components. For more than 20 years, the melanoma genome has been subject to extensive scrutiny, which has led to the identification of several genes that...
Topics
- DNA Methylation
- Epigenesis, Genetic
- Extracellular Signal-Regulated MAP Kinases
- Gene Amplification
- Genes, ras
- Genome, Human
- Humans
- MAP Kinase Kinase Kinases
- Melanoma
- Mutation
- Proto-Oncogene Proteins B-raf