Molecular and cellular pathogenesis of melanoma initiation and progression.

doi:10.1007/s00018-013-1324-2

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Article

Molecular and cellular pathogenesis of melanoma initiation and progression.

Cellular and molecular life sciences : CMLS - 1 Nov 2013

Regad Tarik

Abstract excerpt

Melanoma is a malignant tumor of melanocytes that can spread to other organs of the body, resulting in severe and/or lethal malignancies. Melanocytes are pigment-producing cells found in the deep layer of the epidermis and are originated from melanocytes stem cells through a cellular process called melanogenesis. Several genes and epigenetic and micro-environmental factors are involved in this process via the...

Topics

Animals
Cell Cycle
Cell Differentiation
Cell Proliferation
Cell Transformation, Neoplastic
Disease Progression
Humans
Melanocytes
Melanoma
Mice
MicroRNAs
Mutation
Phenotype
Signal Transduction
Skin Neoplasms
Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 23532409
DOI: 10.1007/s00018-013-1324-2
PMCID: PMC11113476

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