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Article

Integrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer.

Journal of translational medicine - 10 Jun 2024

Zhou Siyu, Tao Baian, Guo Yujie, Gu Jichun, Li Hengchao, Zou Caifeng, Tang Sichong, Jiang Shuheng, Fu Deliang, Li Ji

Abstract excerpt

BACKGROUND: Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment. METHODS: We examined the relationship between genetically determined levels of plasma proteins and PC through a systemic proteome-wide Mendelian randomization (MR) analysis utilizing cis-pQTLs from multiple centers. Rigorous sensitivity analyses,...

Topics

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Blood Proteins
Gene Expression Regulation, Neoplastic
Mendelian Randomization Analysis
Molecular Targeted Therapy
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Reproducibility of Results

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Identifiers

PMID: 38858729
DOI: 10.1186/s12967-024-05363-9
PMCID: PMC11165868

Genes

PC
ABO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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