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Article

Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers.

Journal of the National Cancer Institute - 5 Apr 2024

Sun Jing, Luo Jia, Jiang Fangyuan, Zhao Jianhui, Zhou Siyun, Wang Lijuan, Zhang Dongfeng, Ding Yuan, Li Xue

Abstract excerpt

BACKGROUND: The proteome is an important reservoir of potential therapeutic targets for cancer. This study aimed to examine the causal associations between plasma proteins and cancer risk and to identify proteins with cross-cancer effects. METHODS: Genetic instruments for 3991 plasma proteins were extracted from a large-scale proteomic study. Summary-level data of 13 site-specific cancers were derived from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38039160
DOI: 10.1093/jnci/djad247

Genes

CD86
CXCL10
IL6R
TAPBP
ADPGK
CSF2RA
GZMM
SIGLEC14
SIGLEC5
CLSTN3
NCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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