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The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

1 Apr 2019

Abstract excerpt

The NADPH-dependent oxidase NOX2 is an important effector of immune cell function, and its activity has been linked to oncogenic signaling. Here, we describe a role for NOX2 in leukemia-initiating stem cell populations (LSCs). In a murine model of leukemia, suppression of NOX2 impaired core metabolism, attenuated disease development, and depleted functionally defined LSCs. Transcriptional analysis of purified...

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PMID: 30943405
DOI: 10.1016/j.celrep.2019.03.009

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