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Adaptive resistance to FLT3 inhibitors is potentiated by ROS-driven DNA repair signalling

2024-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Alterations in the FMS-like tyrosine kinase 3 (FLT3) gene are the most frequent driver mutations in acute myeloid leukaemia (AML), linked to a high risk of relapse in patients with internal tandem duplications (FLT3-ITD). Tyrosine kinase inhibitors (TKIs) targeting the FLT3 protein are approved for clinical use, yet resistance often emerges. This resistance is mainly seen following the acquisiti...

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Literature Corpus work
7173042c-62ee-538e-9efe-35d74892ba37
DOI
10.1101/2024.07.26.605229
Open publication

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Adaptive resistance to FLT3 inhibitors is potentiated by ROS-driven DNA repair signallingDOI 10.1101/2024.07.26.605229
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