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The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia

28 Nov 2019

Abstract excerpt

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a poor overall survival. Reactive oxygen species (ROS) have been shown to be elevated in a wide range of cancers including AML. Whilst previously thought to be mere by-products of cellular metabolism, it is now clear that ROS modulate the function of signalling proteins through oxidation of critical cysteine residues. In this way, ROS...

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PMID: 31795243
DOI: 10.3390/ijms20236003

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