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Article

Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy.

The pharmacogenomics journal - 1 Apr 2018

Megías-Vericat J E, Montesinos P, Herrero M J, Moscardó F, Bosó V, Rojas L, Martínez-Cuadrón D, Rodríguez-Veiga R, Sendra L, Cervera J, Poveda J L, Sanz M Á, Aliño S F

Abstract excerpt

Efficacy and toxicity of anthracycline treatment in acute myeloid leukemia (AML) is mediated by reactive oxygen species (ROS). NADPH oxidase is the major endogenous source of ROS and a key mediator of oxidative cardiac damage. The impact of NADPH oxidase polymorphisms (CYBA:rs4673, NCF4:rs1883112, RAC2:rs13058338) was evaluated in 225 adult de novo AML patients. Variant alleles of NCF4 and RAC2 were related to...

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Topics

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Share to Aged
Share to Antineoplastic Combined Chemotherapy Protocols
Share to Induction Chemotherapy
Share to Leukemia, Myeloid, Acute
Share to NADPH Oxidases
Share to rac GTP-Binding Proteins
Share to Reactive Oxygen Species
Share to Remission Induction

Source

Identifiers

PMID: 28485375
DOI: 10.1038/tpj.2017.19

Genes

CYBA
RAC2
NCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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