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Article

Nuclear Nox4-Derived Reactive Oxygen Species in Myelodysplastic Syndromes

1 Jan 2014

Abstract excerpt

A role for intracellular ROS production has been recently implicated in the pathogenesis and progression of a wide variety of neoplasias. ROS sources, such as NAD(P)H oxidase (Nox) complexes, are frequently activated in AML (acute myeloid leukemia) blasts and strongly contribute to their proliferation, survival, and drug resistance. Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders...

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Identifiers

PMID: 24719867
DOI: 10.1155/2014/456937

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