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Article

Target-stabilized base editors enable robust high-fidelity RNA editing.

Nature communications - 25 Feb 2026

Liu Taian, Lin Yunping, Liu Qiwei, Liao Wenhui, Lin Yunyi, Zhang Yujing, Zhang Jianqing, Cao Wenhua, Yang Lixin, Hong Zexuan, Lu Zhonghua

Abstract excerpt

RNA base editing using engineered deaminases represents a powerful tool to correct mutations at the RNA level. However, widespread off-target effects, primarily arising from dissociated free deaminases, remain a significant challenge. Here, we devise the RECODE (RNA editing with conditionally stable and enhanced ADAR1 deaminase variants) system, which employs designer degron-tagged ADAR1 deaminase (ADAR1d) with...

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PMID: 41741438
DOI: 10.1038/s41467-026-69835-w
PMCID: PMC13046768

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