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Article

Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments.

Experimental cell research - 15 Jul 2004

Meyer-Ficca Mirella L, Meyer Ralph G, Coyle Donna L, Jacobson Elaine L, Jacobson Myron K

Abstract excerpt

Poly(ADP-ribose) glycohydrolase (PARG) is the only protein known to catalyze hydrolysis of ADP-ribose (ADPR) polymers to free ADP-ribose. While numerous genes encode different poly(ADP-ribose) polymerases (PARPs) that all synthesize ADP-ribose polymer, only a single gene coding for PARG has been detected in mammalian cells. Here, we describe two splice variants of human PARG mRNA, which lead to expression of PARG...

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Source

Identifiers

PMID: 15212953
DOI: 10.1016/j.yexcr.2004.03.050

Genes

PARG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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