Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos

Abstract excerpt

<h4>Summary</h4> Toxic cellular insults activate the nuclear protein poly (ADP-ribose) (PAR) polymerase-1 (PARP-1) to initiate parthanatos, a regulated cell death program. PAR acts as a death signal by translocating from the nucleus to the cytosol, where it activates the next steps in the parthanatic cell death cascade. How PAR translocates from the nucleus to the cytosol is not known. Here we show that PARylatio...

Topics

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• Calcium signaling and nucleotide metabolism
• Cell death mechanisms and regulation
• Integrated Circuits and Semiconductor Failure Analysis
• Parkinson's Disease Mechanisms and Treatments
• PARP inhibition in cancer therapy
• RNA Research and Splicing
• Signaling Pathways in Disease
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

184d0805-9240-5dc4-8985-1e02131edd40

DOI

10.1101/2023.06.18.545460