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Article

A Double-Edged Sword: The Two Faces of PARylation

29 Aug 2022

Abstract excerpt

Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally, studies on PARylation were confined to PARP-1 activation in the DNA repair pathway. However, the interplay between PARylation and DNA repair suggests that...

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PMID: 36077221
DOI: 10.3390/ijms23179826

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