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Article

PARG Inhibitors and Functional PARG Inhibition Models.

Current protein & peptide science - 1 Jan 2016

Sasaki Yuka, Hozumi Miyuki, Fujimori Hiroaki, Murakami Yasufumi, Koizumi Fumiaki, Inoue Kengo, Masutani Mitsuko

Abstract excerpt

Poly(ADP-ribose) polymerases (PARPs) family proteins catalyze poly(ADP-ribosylation) (PARylation) by conjugating ADP-ribose residues repeatedly on amino acid residues using nicotinamide adenine dinucleotide as a substrate. The inhibitors of PARP widely block DNA repair processes and are currently examined in clinical trials of cancer therapy. Poly(ADP-ribose) glycohydrolase (PARG) is the main nuclear enzyme,...

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Identifiers

PMID: 27817742
DOI: 10.2174/1389203717666160419145130

Genes

PARG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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