Article

Integrative multi-omics reveal glial signatures associated with accelerated cognitive decline in Alzheimer’s disease

2024-08-28

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder characterised by progressive cognitive decline and memory loss caused by both genetic and environmental factors. Synapse dysfunction and loss are strongly related to cognitive decline in AD. This study integrates genomic, transcriptomic, proteomic and immunohistological (multi-omics) data and longitudinal cognitive data across several AD cohorts to elucidate...

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Literature Corpus work: de9e93ef-bdf3-5839-b0ea-8e516ea7736b
DOI: 10.1101/2024.08.27.24312641

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