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Article

Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia.

Neurology - 31 Jul 2018

Merluzzi Andrew P, Carlsson Cynthia M, Johnson Sterling C, Schindler Suzanne E, Asthana Sanjay, Blennow Kaj, Zetterberg Henrik, Bendlin Barbara B

Abstract excerpt

OBJECTIVE: To test the hypothesis that cognitively unimpaired individuals with Alzheimer disease (AD) neuropathology differ from individuals with AD dementia on biomarkers of neurodegeneration, synaptic dysfunction, and glial activation. METHODS: In a cross-sectional study, adult participants >70 years old (n = 79, age 77.1 ± 5.3 years) underwent comprehensive cognitive evaluation and CSF collection, which was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29959263
DOI: 10.1212/WNL.0000000000005901
PMCID: PMC6093766

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