Article

AHA1 regulates Aβ production via modulation of APP expression and γ-secretase assembly

2025-11-04

Abstract excerpt

Deposition of amyloid β-protein (Aβ) is a hallmark of Alzheimer’s disease (AD), produced by γ-secretase–mediated cleavage of amyloid precursor protein (APP). The 90-kDa heat shock protein (Hsp90) co-chaperone, activator of Hsp90 ATPase homolog 1 (AHA1), is known to promote the accumulation of toxic tau species; however, its effects on Aβ production remain unclear. Here, we show that knockdown of endogenous AHA1 de...

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Literature Corpus work: 1e33ecc3-987c-5502-8331-fbb3631fde83
DOI: 10.1101/2025.11.03.686106

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