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β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

4 Dec 2012

Abstract excerpt

Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype 1) precomplex and mature γ-secretase complex through its functional interaction with APH-1. Deficiency of β-arrestin1 or...

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PMID: 23208420
DOI: 10.1038/cr.2012.167

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