Article
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.
Molecular biology of the cell - 15 Mar 2010
Koulov Atanas V, LaPointe Paul, Lu Bingwen, Razvi Abbas, Coppinger Judith, Dong Meng-Qiu, Matteson Jeanne, Laister Rob, Arrowsmith Cheryl, Yates John R, Balch William E
Abstract excerpt
The activator of Hsp90 ATPase 1, Aha1, has been shown to participate in the Hsp90 chaperone cycle by stimulating the low intrinsic ATPase activity of Hsp90. To elucidate the structural basis for ATPase stimulation of human Hsp90 by human Aha1, we have developed novel mass spectrometry approaches that demonstrate that the N- and C-terminal domains of Aha1 cooperatively bind across the dimer interface of Hsp90 to...
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