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Article

Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Apr 2011

Hoshino Tatsuya, Murao Naoya, Namba Takushi, Takehara Masaya, Adachi Hiroaki, Katsuno Masahisa, Sobue Gen, Matsushima Takahide, Suzuki Toshiharu, Mizushima Tohru

Abstract excerpt

Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Aβ is generated by proteolysis of β-amyloid precursor protein (APP) and is cleared by enzyme-mediated degradation and phagocytosis by microglia and astrocytes. Some cytokines, such as TGF-β1, stimulate this phagocytosis. In contrast, cellular upregulation of HSP70 expression provides cytoprotection against Aβ. HSP70...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21471357
DOI: 10.1523/JNEUROSCI.5478-10.2011
PMCID: PMC6622695

Genes

APP

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